This site relies on JavaScript which is currently disabled in your browser. Some functionality will be missing as a result. 2024 Evaluating the biocompatibility of ceramic materials for constructing artificial reefs LM O’Reilly, SM Willerth Frontiers in Marine Science 10, 1292584, 2024Modeling the neuroimmune system in Alzheimer’s and Parkinson’s diseases W Balestri, R Sharma, VA da Silva, BC Bobotis, AJ Curle, V Kothakota, ... Journal of Neuroinflammation 21 (1), 32, 2024Next generation in vitro models of the human blood-brain/cerebrospinal fluid barrier R Daughters, LM Julian, E Knock, SM Willerth Frontiers in Molecular Neuroscience 17, 1371733, 2024Bioprinting functional neural networks SM Willerth Cell Stem Cell 31 (2), 151-152, 20242023 3D bioprinting complex models of cancer R Sharma, MR Perez, VA da Silva, J Thomsen, L Bhardwaj, TAM Andrade, ... Biomaterials Science 11 (10), 3414-3430, 2023Optimization of precision nanofiber micelleplexes for DNA delivery STG Street, HC Parkin, L Shopperly, J Chrenek, K Letwin, SM Willerth, ... Biomaterials Science 11 (10), 3512-3523, 2023Novel biomaterial strategies for osteogenic treatments SM Willerth, JW Giles, GCJ Lindberg Frontiers in Bioengineering and Biotechnology 11, 1137760, 2023Utilizing Additive Manufacturing to Produce Organ Mimics and Imaging Phantoms D Karaman, SM Willerth Surgeries 4 (1), 58-72, 2023Protocol for 3D Bioprinting Mesenchymal Stem Cell–derived Neural Tissues Using a Fibrin-based Bioink MR Perez, NZ Masri, J Walters-Shumka, S Kahale, SM Willerth Bio-protocol 13 (9), 20233D bioprinting patient-derived induced pluripotent stem cell models of Alzheimer’s disease using a smart bioink C Benwood, J Walters-Shumka, K Scheck, SM Willerth Bioelectronic Medicine 9 (1), 10, 20233D-bioprinted cardiac tissues and their potential for disease modeling MR Perez, VA da Silva, PE Cortez, B Joddar, SM Willerth Journal of 3D printing in medicine 7 (2), 3DP6, 2023hiPSC-derived GRN-deficient astrocytes delay spiking activity of developing neurons C Lee, J Frew, NL Weilinger, S Wendt, W Cai, S Sorrentino, X Wu, ... Neurobiology of Disease 181, 106124, 2023Recent advances in personalized 3D bioprinted tissue models JP Walters-Shumka, S Sorrentino, HB Nygaard, SM Willerth MRS Bulletin 48 (6), 632-642, 2023Differentiation of peritubular myoid‐like cells from human induced pluripotent stem cells M Robinson, A Haegert, YY Li, T Morova, AYY Zhang, L Witherspoon, ... Advanced Biology 7 (7), 2200322, 20233D bioprinting for organ and organoid models and disease modeling AC Juraski, S Sharma, S Sparanese, VA da Silva, J Wong, Z Laksman, ... Expert Opinion on Drug Discovery 18 (9), 1043-1059, 2023The Impact of Biomaterial Surface Properties on Engineering Neural Tissue for Spinal Cord Regeneration VA da Silva, BC Bobotis, FF Correia, TH Lima-Vasconcellos, ... International Journal of Molecular Sciences 24 (17), 13642, 2023Machine Learning Approaches to 3D Models for Drug Screening VA da Silva, R Sharma, E Shteinberg, V Patel, L Bhardwaj, T Garay, B Yu, ... Biomedical Materials & Devices, 1-26, 20232022 Engineering brain and spinal cord tissue constructs M Modo, K Lampe, S Willerth Brain research bulletin 178, 131-132, 2022Characterizing the Mechanical Performance of a Bare-Metal Stent with an Auxetic Cell Geometry SK Bhullar, H Lekesiz, AA Karaca, Y Cho, SM Willerth, MBG Jun Applied Sciences 12 (2), 910, 2022Smart Bioinks for the Printing of Human Tissue Models Z Maan, NZ Masri, SM Willerth Biomolecules 12 (1), 141, 2022Trends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia ALR Costa, SM Willerth, LG de la Torre, SW Han Materials Today Bio 13, 100221, 2022The effect of SARS-CoV-2 on the nervous system: a review of neurological impacts caused by human coronaviruses C Day, C Studders, K Arklie, A Kaur, K Teetzen, R Kirsch, L Abelseth, ... Reviews in the Neurosciences 33 (3), 257-268, 2022Using clinically derived human tissue to 3-dimensionally bioprint personalized testicular tubules for in vitro culturing: first report M Robinson, E Bedford, L Witherspoon, SM Willerth, R Flannigan F&S Science 3 (2), 130-139, 2022Protocol for printing 3D neural tissues using the BIO X equipped with a pneumatic printhead J Chrenek, R Kirsch, K Scheck, SM Willerth STAR protocols 3 (2), 101348, 2022Microfluidic Generation of Therapeutically Relevant Polycaprolactone (PCL) Microparticles: Computational and Experimental Approaches A Forigua, A Dalili, R Kirsch, SM Willerth, KS Elvira ACS Applied Polymer Materials 4 (10), 7004-7013, 2022Testing specificity and sensitivity of wastewater-based epidemiology for detecting SARS-CoV-2 in four communities on Vancouver Island, Canada NZ Masri, KG Card, EA Caws, A Babcock, R Powell, CJ Lowe, S Donovan, ... Environmental advances 9, 100310, 2022Length-Controlled Nanofiber Micelleplexes as Efficient Nucleic Acid Delivery Vehicles STG Street, J Chrenek, RL Harniman, K Letwin, JM Mantell, U Borucu, ... Journal of the American Chemical Society 144 (43), 19799-19812, 2022Using nanomaterials to address SARS-CoV-2 variants through development of vaccines and therapeutics MV Hangad, S Keshvani, N Kelpin, J Walters-Shumka, MK Hood, C Volk, ... Frontiers in Materials 9, 1039247, 20222021 Strategies for delivering online biomedical engineering electives during the COVID-19 pandemic JW Giles, SM Willerth Biomedical Engineering Education 1, 115-120, 2021Natural Biomaterials and Their Use as Bioinks for Printing Tissues C Benwood, J Chrenek, RL Kirsch, NZ Masri, H Richards, K Teetzen, ... Bioengineering 8 (2), 27, 20213D tissue models as an effective tool for studying viruses and vaccine development N Lawko, C Plaskasovitis, C Stokes, L Abelseth, I Fraser, R Sharma, ... Frontiers in Materials 8, 631373, 2021Stem Cell Systems Bioengineering Y Lei, SM Willerth, TG Fernandes Frontiers in Bioengineering and Biotechnology 9, 693107, 2021Recent advances in the design of microfluidic technologies for the manufacture of drug releasing particles A Forigua, RL Kirsch, SM Willerth, KS Elvira Journal of Controlled Release 333, 258-268, 2021Physical and Mechanical Characterization of Fibrin-Based Bioprinted Constructs Containing Drug-Releasing Microspheres for Neural Tissue Engineering Applications R Sharma, R Kirsch, KP Valente, MR Perez, SM Willerth Processes 9 (7), 1205, 2021Effect of bioactive Biosilicate®/F18 glass scaffolds on osteogenic differentiation of human adipose stem cells CP Marin, GL Santana, M Robinson, SM Willerth, MC Crovace, ... Journal of Biomedical Materials Research Part A 109 (8), 1293-1308, 20213D Bioprinting Human‐Induced Pluripotent Stem Cells and Drug‐Releasing Microspheres to Produce Responsive Neural Tissues L De la Vega, L Abelseth, R Sharma, J Trivino-Paredes, M Restan, ... Advanced NanoBiomed Research 1 (8), 2000077, 20213D Bioprinting Mesenchymal Stem Cell-Derived Neural Tissues Using a Fibrin-Based Bioink M Restan Perez, R Sharma, NZ Masri, SM Willerth Biomolecules 11 (8), 1250, 20213D Printing for Medical Applications: Current State of the Art and Perspectives during the COVID-19 Crisis A Hagen, M Chisling, K House, T Katz, L Abelseth, I Fraser, S Bradley, ... Surgeries 2 (3), 244-259, 2021Evaluation of 3D-printer settings for producing personal protective equipment C Studders, I Fraser, JW Giles, SM Willerth Journal of 3D printing in medicine 5 (3), 133-144, 2021Drug‐releasing Microspheres for Stem Cell Differentiation R Sharma, C Benwood, SM Willerth Current Protocols 1 (12), e331, 20212020 Quantitative Analysis of the Rewiring of Signaling Pathways to Alter Cancer Cell Fate RM Schmitz, SM Willerth, G van Rensburg, R Edwards Journal of Medical and Biological Engineering 40, 41-52, 2020Determining the mechanism behind yoga’s effects on preventing the symptoms of Alzheimer’s disease A Hassan, M Robinson, SM Willerth Neural regeneration research 15 (2), 261-262, 20203D bioprinting pluripotent stem cell derived neural tissues using a novel fibrin bioink containing drug releasing microspheres R Sharma, IPM Smits, L De La Vega, C Lee, SM Willerth Frontiers in bioengineering and biotechnology 8, 57, 2020CRISPR, prime editing, optogenetics, and DREADDs: new therapeutic approaches provided by emerging technologies in the treatment of spinal cord injury V Paschon, FF Correia, BC Morena, VA da Silva, GB Dos Santos, ... Molecular neurobiology 57, 2085-2100, 2020Three-dimensional bioprinting healthy and diseased models of the brain tissue using stem cells K Walus, S Beyer, SM Willerth Current Opinion in Biomedical Engineering 14, 25-33, 2020Extrusion and Microfluidic‐Based Bioprinting to Fabricate Biomimetic Tissues and Organs E Davoodi, E Sarikhani, H Montazerian, S Ahadian, M Costantini, ... Advanced Materials Technologies 5 (8), 1901044, 2020Novel N-cadherin antagonist causes glioblastoma cell death in a 3D bioprinted co-culture model IPM Smits, OW Blaschuk, SM Willerth Biochemical and Biophysical Research Communications 529 (2), 162-168, 2020The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling C Lee, SM Willerth, HB Nygaard Progress in Neurobiology 192, 101804, 2020Metal additive manufacturing: Technology, metallurgy and modelling S Cooke, K Ahmadi, S Willerth, R Herring Journal of Manufacturing Processes 57, 978-1003, 2020Morphogenic compound-releasing microspheres and use in bioink A Agbay, L De La Vega, SM Willerth US Patent App. 16/971,634, 20202019 Electrospun Nanofibers for Diverse Applications SM Willerth Academic Press, 2019Direct Reprogramming Somatic Cells into Functional Neurons: A New Approach to Engineering Neural Tissue In Vitro and In Vivo M Robinson, O McKee-Reed, K Letwin, SM Willerth Regenerative Medicine and Plastic Surgery: Skin and Soft Tissue, Bone …, 20191.12 Electrospun Nanofibers for Diverse Applications SM Willerth Comprehensive Nanoscience and Nanotechnology, 275, 2019Advancements in Canadian Biomaterials and Implications for Neurotraumatic Diagnosis and Therapies S Chen, AM Auriat, T Li, TR Stumpf, R Wylie, X Chen, SM Willerth, ... MDPI, 2019Bioprinting a novel glioblastoma tumor model using a fibrin-based bioink for drug screening C Lee, E Abelseth, L de la Vega, SM Willerth Materials Today Chemistry 12, 78-84, 2019A Novel Toolkit for Characterizing the Mechanical and Electrical Properties of Engineered Neural Tissues M Robinson, KP Valente, SM Willerth Biosensors 9 (2), 51, 2019Advancements in Canadian biomaterials research in neurotraumatic diagnosis and therapies S Chen, AM Auriat, T Li, TR Stumpf, R Wylie, X Chen, SM Willerth, ... Processes 7 (6), 336, 2019Modeling the Effects of Yoga on the Progression of Alzheimer’s Disease in a Dish A Hassan, M Robinson, SM Willerth Cells Tissues Organs 206 (4-5), 263-271, 20193D bioprinting models of neural tissues: the current state of the field and future directions L de la Vega, C Lee, R Sharma, M Amereh, SM Willerth Brain research bulletin 150, 240-249, 20193D Printing Breast Tissue Models: A Review of Past Work and Directions for Future Work C Cleversey, M Robinson, SM Willerth Micromachines 10 (8), 501, 2019A Visible Light-Cross-Linkable, Fibrin–Gelatin-Based Bioprinted Construct with Human Cardiomyocytes and Fibroblasts S Anil Kumar, M Alonzo, SC Allen, L Abelseth, V Thakur, J Akimoto, Y Ito, ... ACS Biomaterials Science & Engineering 5 (9), 4551-4563, 2019The 2019 Young Innovators of Cellular and Molecular Bioengineering MR King, S Willerth Cellular and Molecular Bioengineering 12, 355-356, 2019How can microsphere-mediated delivery of small molecules serve as a novel tool for engineering tissues from stem cells? SM Willerth Therapeutic delivery 10 (11), 671-674, 20192018 3D bioprinting human induced pluripotent stem cell-derived neural tissues using a novel lab-on-a-printer technology L Vega, DAR Gomez, E Abelseth, L Abelseth, VA Silva, SM Willerth Applied Sciences (Web) 8 (12), 2414, 2018Guggulsterone-releasing microspheres direct the differentiation of human induced pluripotent stem cells into neural phenotypes A Agbay, L De La Vega, G Nixon, S Willerth Biomedical Materials 13 (3), 034104, 20183D Bioprinting Stem Cell Derived Tissues N Tasnim, L De la Vega, SA Kumar, L Abelseth, M Alonzo, M Amereh, ... Cellular and Molecular Bioengineering 11 (4), 219-240, 2018Direct reprogramming of glioblastoma cells into neurons using small molecules C Lee, M Robinson, SM Willerth ACS chemical neuroscience 9 (12), 3175-3185, 2018Biomaterial Scaffolds for Human Embryonic Stem Cell Culture and Differentiation S Willerth, DV Schaffer Molecular, Cellular, and Tissue Engineering, 32-1-32-16, 2018Using Biomaterials to Deliver Cells In Vivo for Neural Tissue Engineering Applications L de la Vega, M Thomas, SM Willerth Biomaterials for Cell Delivery, 107-138, 2018Transdifferentiating astrocytes into neurons using ASCL1 functionalized with a novel intracellular protein delivery technology M Robinson, I Fraser, E McKee, K Scheck, L Chang, SM Willerth Frontiers in Bioengineering and Biotechnology 6, 173, 20183D printing of neural tissues derived from human induced pluripotent stem cells using a fibrin-based bioink E Abelseth, L Abelseth, L De la Vega, ST Beyer, SJ Wadsworth, ... ACS Biomaterials Science & Engineering 5 (1), 234-243, 2018Bioprinting neural tissues using stem cells as a tool for screening drug targets for Alzheimer’s disease SM Willerth Journal of 3D printing in medicine 2 (4), 163-165, 2018Engineering neural tissue from human pluripotent stem cells using novel small molecule releasing microspheres L De la Vega, K Karmirian, SM Willerth Advanced Biosystems 2 (12), 1800133, 20183D Bioprinting Human Induced Pluripotent Stem Cell-Derived Neural Tissues Using a Novel Lab-on-a-Printer Technology L de la Vega, D A Rosas Gómez, E Abelseth, L Abelseth, ... Applied Sciences 8 (12), 2414, 20182017 Melt electrospinning in tissue engineering SM Willerth Electrospun Materials for Tissue Engineering and Biomedical Applications, 87-100, 20175.8 Scaffold Materials for Human Embryonic Stem Cell Culture and Differentiation D Schaffer, S Willerth Elsevier, 2017Biomimetic strategies for replicating the neural stem cell niche SM Willerth Current Opinion in Chemical Engineering 15, 8-14, 2017Fibrin hydrogels induce mixed dorsal/ventral spinal neuron identities during differentiation of human induced pluripotent stem cells JM Edgar, M Robinson, SM Willerth Acta biomaterialia 51, 237-245, 2017Emerging biofabrication strategies for engineering complex tissue constructs RD Pedde, B Mirani, A Navaei, T Styan, S Wong, M Mehrali, A Thakur, ... Advanced Materials 29 (19), 1606061, 2017Engineering Neural Tissue from Stem Cells S Willerth Academic Press, 2017Mechanically stable fibrin scaffolds promote viability and induce neurite outgrowth in neural aggregates derived from human induced pluripotent stem cells M Robinson, S Douglas, S Michelle Willerth Scientific reports 7 (1), 6250, 2017An Affordable Microsphere-Based Device for Visual Assessment of Water Quality A Rajwani, B Restall, NJ Muller, S Roebuck, SM Willerth Biosensors 7 (3), 31, 2017Commercializing electrospun scaffolds for pluripotent stem cell-based tissue engineering applications NK Mohtaram, V Karamzadeh, Y Shafieyan, SM Willerth Electrospinning 1 (1), 62-72, 20173-D Bioprinting of Neural Tissue for Applications in Cell Therapy and Drug Screening M Thomas, SM Willerth Frontiers in bioengineering and biotechnology 5, 69, 2017Modeling the behavior of human induced pluripotent stem cells seeded on melt electrospun scaffolds ME Hall, NK Mohtaram, SM Willerth, R Edwards Journal of Biological Engineering 11, 1-20, 2017Localized tacrolimus delivery repairs the damaged central nervous system SM Willerth EBioMedicine 26, 4-5, 20172016 Functionalizing Ascl1 with novel intracellular protein delivery technology for promoting neuronal differentiation of human induced pluripotent stem cells M Robinson, P Chapani, T Styan, R Vaidyanathan, SM Willerth Stem Cell Reviews and Reports 12, 476-483, 2016Engineering personalized neural tissue using functionalized transcription factors SM Willerth Neural Regeneration Research 11 (10), 1570-1571, 2016Biomaterial strategies for delivering stem cells as a treatment for spinal cord injury A Agbay, JM Edgar, M Robinson, T Styan, K Wilson, J Schroll, J Ko, ... Cells Tissues Organs 202 (1-2), 42-51, 20162015 Engineering personalized neural tissue by combining induced pluripotent stem cells with fibrin scaffolds A Montgomery, A Wong, N Gabers, SM Willerth Biomaterials Science 3 (2), 401-413, 2015Optimizing Differentiation Protocols for Producing Dopaminergic Neurons from Human Induced Pluripotent Stem Cells for Tissue Engineering Applications: Supplementary Issue: Stem … M Robinson, S Yau, L Sun, N Gabers, E Bibault, BR Christie, SM Willerth Biomarker insights 10, BMI. S20064, 2015Development of a glial cell-derived neurotrophic factor-releasing artificial dura for neural tissue engineering applications NK Mohtaram, J Ko, A Agbay, D Rattray, PO Neill, A Rajwani, ... Journal of Materials Chemistry B 3 (40), 7974-7985, 2015Mathematical model for predicting topographical properties of poly (ε-caprolactone) melt electrospun scaffolds including the effects of temperature and linear transitional speed J Ko, NK Mohtaram, PC Lee, SM Willerth, MBG Jun Journal of Micromechanics and Microengineering 25 (4), 045018, 2015Neural Tissue Engineering: Applications NK Mohtaram, A Montgomery, JC Gomez, A Agbay, S Willerth Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 11 Volume …, 2015Electrospun biomaterial scaffolds with varied topographies for neuronal differentiation of human‐induced pluripotent stem cells NK Mohtaram, J Ko, C King, L Sun, N Muller, MBG Jun, SM Willerth Journal of Biomedical Materials Research Part A 103 (8), 2591-2601, 2015Incorporation of retinoic acid releasing microspheres into pluripotent stem cell aggregates for inducing neuronal differentiation JC Gomez, JM Edgar, AM Agbay, E Bibault, A Montgomery, NK Mohtaram, ... Cellular and Molecular Bioengineering 8, 307-319, 20152014 Combining protein-based biomaterials with stem cells for spinal cord injury repair A Montgomery, A Agbay, JM Edgar, N Gabers, J Gomez, NK Mohtaram, ... OA Publishing London, 2014Fabrication of poly (ϵ-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applications J Ko, NK Mohtaram, F Ahmed, A Montgomery, M Carlson, PCD Lee, ... Journal of Biomaterials Science, Polymer Edition 25 (1), 1-17, 2014Controlled release of glial cell line-derived neurotrophic factor from poly (ε-caprolactone) microspheres A Agbay, NK Mohtaram, SM Willerth Drug delivery and translational research 4, 159-170, 2014Using mathematical modeling to control topographical properties of poly (ε-caprolactone) melt electrospun scaffolds J Ko, SK Bhullar, NK Mohtaram, SM Willerth, MBG Jun Journal of Micromechanics and Microengineering 24 (6), 065009, 2014Multifunctional electrospun scaffolds for promoting neuronal differentiation of induced pluripotent stem cells NK Mohtaram, J Ko, A Montgomery, M Carlson, L Sun, A Wong, ... Journal of Biomaterials and Tissue Engineering 4 (11), 906-914, 20142012 Towards high throughput tissue engineering: development of chitosan-calcium phosphate scaffolds for engineering bone tissue from embryonic stem cells J Ko, K Kolehmainen, F Ahmed, MBG Jun, SM Willerth American journal of stem cells 1 (1), 81, 2012Preparation of 3D fibrin scaffolds for stem cell culture applications K Kolehmainen, SM Willerth JoVE (Journal of Visualized Experiments), e3641, 2012Biomaterial Scaffolds for Human Embryonic Stem Cell Culture and Differentiation D Schaffer, JD Bronzino, DR Peterson, S Willerth, D Schaffer Stem Cell Engineering: Principles and Practices, 1-16, 20122009 Erratum to “The effect of controlled growth factor delivery on embryonic stem cell differentiation inside fibrin scaffolds”[Stem Cell Res 1 (2008) 205–218] SM Willerth, A Rader, SE Sakiyama-Elbert Stem Cell Research 2 (3), 231, 2009The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages J Xie, SM Willerth, X Li, MR Macewan, A Rader, SE Sakiyama-Elbert, ... Biomaterials 30 (3), 354-362, 2009Kinetic Analysis of Neurotrophin-3–Mediated Differentiation of Embryonic Stem Cells into Neurons SM Willerth, SE Sakiyama-Elbert Tissue Engineering Part A 15 (2), 307-318, 2009Conductive core–sheath nanofibers and their potential application in neural tissue engineering J Xie, MR MacEwan, SM Willerth, X Li, DW Moran, SE Sakiyama‐Elbert, ... Advanced functional materials 19 (14), 2312-2318, 20092008 The effect of controlled delivery of growth factors on embryonic stem cell differentiation inside of fibrin scaffolds SM Willerth ProQuest, 2008Cell therapy for spinal cord regeneration SM Willerth, SE Sakiyama-Elbert Advanced drug delivery reviews 60 (2), 263-276, 2008Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery SM Willerth, SE Sakiyama-Elbert Harvard Stem Cell Institute, 2008The effect of controlled growth factor delivery on embryonic stem cell differentiation inside fibrin scaffolds SM Willerth, A Rader, SE Sakiyama-Elbert Stem cell research 1 (3), 205-218, 20082007 Rationally designed peptides for controlled release of nerve growth factor from fibrin matrices SM Willerth, PJ Johnson, DJ Maxwell, SR Parsons, ME Doukas, ... Journal of Biomedical Materials Research Part A: An Official Journal of The …, 2007Approaches to neural tissue engineering using scaffolds for drug delivery SM Willerth, SE Sakiyama-Elbert Advanced drug delivery reviews 59 (4-5), 325-338, 2007The effects of soluble growth factors on embryonic stem cell differentiation inside of fibrin scaffolds SM Willerth, TE Faxel, DI Gottlieb, SE Sakiyama‐Elbert Stem Cells 25 (9), 2235-2244, 2007